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KMID : 1189420140270030115
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2014 Volume.27 No. 3 p.115 ~ p.132
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Effects of Portulacae Herba (PH) on Allergic Contact Dermatitis (ACD) Induced by DNCB in Mice
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Lee Jong-Cheol
Park Soo-Yeon
Choi Jeong-Hwa
Kim Jong-Han
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Abstract
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Objective : Portulacae Herba (PH) can clear away heat, detoxicate, cool down blood heat. The present study was designed to investigate the effects of PH on ACD induced by 2,4-dinitrochlorobenzene (DNCB) in mice.
Method : In this experiment, the effects of PH on changes in body weights, thicknesses and weights of ear, thicknesses of dorsum skin, degree of symptoms on the dorsum skin, histopathological changes of ear and dorsum skin, spleen weights, TNF-α and IL-10 in serum were observed. And the effects on the proliferation rates of splenocytes were also investigated in vitro and in vivo.
Results : 1. PH spread (PHS) group and PH spread plus administered (PHS+Adm) group didn’t show any changes in weight and thickness of ear. 2. But in PHS and PHS+Adm group, thickness of dorsum skin decreased significantly. 3. And PHS and PHS+Adm group showed meaningful effectiveness on ACD symptoms like erythema, desquamation and keratinization. 4. In histopathological observation, hyperplasia and edema of spongy tissues were remarkably diminished in PHS and PHS+Adm group. 5. And PH reduced the proliferation rates of splenocytes in vivo and vitro study.
Conclusions : PH effectively decreased symptoms of ACD in this study, therefore PH can be one of medicinal ingredients to treat ACD.
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KEYWORD
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Portulacae Herba (PH), Allergic Contact Dermatitis (ACD), 2, 4-dinitrochlorobenzene (DNCB), IL-10
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